Demi Moore reveals why she nearly stepped away from acting before landing her Golden Globe-nominated role in The Substance. The 2024 body horror film, directed by Coralie Fargeat, stars Moore as Elisabeth Sparkle, a faded Hollywood star who resorts to a black-market drug to regain her youth, unleashing a grotesque and horrifying consequence. Margaret Qualley co-stars as Sue, Elisabeth’s younger, better version of herself. The film, known for its shocking practical effects and biting commentary on society's obsession with youth, premiered to critical acclaim at Cannes, where Fargeat won Best Screenplay.