Manchester City v Manchester United: Premier League – live

Premier League updates from the 4.30pm BST kick-off

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Pep Guardiola has made six changes to the team that lost at Brighton a fortnight ago. Gianluigi Donnarumma, Ruben Dias, Josko Gvardiola, Nico O’Reilly, Phil Foden and Jeremy Doku come in for James Trafford, Matheus Nunes, John Stones, Rayan Ait-Nouri, Oscar Bobb and Omar Marmoush.

The environment is akin to England after the reliance on W-M and the winger was shattered by Hungary in 1953, or 19th-century Europe after scientific discoveries had provoked the crisis of faith. If none of the previous assumptions are true, if we cannot trust the old doctrine, how do we know what is right?

This is the world that produced Charles Darwin and Friedrich Nietzsche and had Arthur Conan Doyle attending seances and believing in fairies, just as managers in the 50s started trialling strike pairings and back fours and had the Doncaster manager Peter Doherty assigning players with random numbers to spread confusion. Nobody knows what is true any more, and the consequence is a chaotic world of experimentation.