Every Grey's Anatomy Spinoff Explained (& How They Connect)

There are several different Grey’s Anatomy spinoff shows connecting to the main series, continuing the legacy of one of the longest-running and most popular shows in TV history. The series premiered its 23rd season in 2026 and shows no signs of slowing down. Grey’s Anatomy follows the basic premise of medical dramas, telling the stories of surgical interns, residents, and attendings as they do their best to balance their personal and professional lives, which end up overlapping most of the time. The series was led by Meredith Grey (Ellen Pompeo), one of the few characters from season 1 that lasted to season 19.