Natural compound could help fight aggressive leukemia and amplify the effect of chemotherapy drugs (Forskolin)

Forskolin, a natural compound derived from a plant, could significantly improve treatment outcomes for an aggressive form of leukemia, known as KMT2A-rearranged Acute Myeloid Leukemia (KMT2A-r AML), according to a new study. The study shows that not only does forskolin directly stop the growth of leukemia cells, but it also enhances the effectiveness of chemotherapy drugs. Researchers from Surrey found that forskolin activates Protein Phosphatase 2A (PP2A) and stops the expression of several cancer-promoting genes (MYC, HOXA9 and HOXA10). The research also shows a significant and unexpected finding, as forskolin was found to substantially increase the sensitivity of KMT2A-r AML...