Middle East crisis live: Vance warns Iran not to ‘play’ US as he heads to Pakistan for talks

Vice-president leading US delegation in negotiations due to take place in Islamabad on Saturday

Netanyahu says there is no ceasefire in Lebanon as Israel launches fresh strikes

The streets of Islamabad are on strict lockdown as Pakistan’s capital prepares to play host to historic negotiations between Iran and the US that have dangled the promise of an end to war that has devastated the Middle East.

Even as the US-Iran ceasefire looked increasingly precarious, amid Israel’s continued bombardment of Lebanon and disputes over the terms of the talks, Pakistani officials insist that the make-or-break peace negotiations will be going ahead over the weekend as planned